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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Eur J Med Chem. 2017 Oct 31;143:1790–1806. doi: 10.1016/j.ejmech.2017.10.076

Figure 1.

Figure 1

Chemical structures of the FDA-approved drugs SAHA, Belinostat, and Panobinostat, the C4-modified SAHA analogs reported here, and several isoform selective HDAC inhibitors discussed in the text (MS-275, Tubastatin, PCI-34051, BRD-73954, Valpropylhydroxamic acid, Aminotetralin 32, C2-hexyl SAHA, and C5-benzyl SAHA).