Table 2.

Association between migraine and suicidal behaviors by psychiatric disorder status (N = 156,172,826)

Suicidal behaviors	With migraine (N = 2,190,305)	Without migraine (N = 153,982,521)	OR (95% CI)
			Unadjusted	Adjusteda
No suicidal behavior	2,097,808	151,505,167	Reference	Reference
Suicidal behavior	92,497	2,477,354	2.69 (2.55, 2.86)	2.07 (1.96, 2.19)
Stratified by depression
With depression (N = 17,961,785)
No suicidal behavior	556,429	15,962,426	Reference	Reference
Suicidal behavior	55,433	1,387,497	1.15 (1.08, 1.21)	0.80 (0.76, 0.85)
Without depression (N = 138,211,041)
No suicidal behavior	1,541,379	135,542,741	Reference	Reference
Suicidal behavior	37,064	1,089,857	2.99 (2.80, 3.20)	2.35 (2.20, 2.51)
Stratified by anxiety
With anxiety (N = 7,670,390)
No suicidal behavior	255,719	7,061,486	Reference	Reference
Suicidal behavior	20,698	332,487	1.72 (1.63, 1.82)	1.07 (1.02, 1.13)
Without anxiety (N = 148,502,437)
No suicidal behavior	1,842,089	144,443,681	Reference	Reference
Suicidal behavior	71,799	2,144,868	2.63 (2.46, 2.80)	2.06 (1.94, 2.20)
Stratified by PTSD
With PTSD (N = 840,339)
No suicidal behavior	40,500	608,209	Reference	Reference
Suicidal behavior	13,929	177,701	1.18 (1.11, 1.25)	1.00 (0.94, 1.07)
Without PTSD (N = 155,332,488)
No suicidal behavior	2,057,308	150,896,959	Reference	Reference
Suicidal behavior	78,568	2,299,653	2.51 (2.36, 2.67)	1.95 (1.84, 2.08)

Individual cell counts may not add up to the global cell counts because of rounding and the differences arising from variance computations when using the discharge weights. Percentages may not add up to 100% due to rounding, missing data, or data falling into categories too small to report.

Abbreviations: OR, odds ratio; CI, confidence interval; PTSD, Posttraumatic stress disorder

^aAdjusted for age (continuous), sex, race, median household income quartiles for patient zip code, hospital location, hospital region, year, and age-adjusted Charlson Comorbidity Index.