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(A) Antiviral activity of MAA and SNA lectins against the wild-type CA/04 virus as determined by virus reduction assay in Calu-3 cells. (B) Generation of influenza A viruses with decreased sensitivity to MAA and SNA lectins. CA/04 virus was passaged in Calu-3 cells in the presence or absence of increasing concentrations of MAA or SNA lectins. *P < 0.05, °P < 0.01, compared to the values for the CA/04 virus.
