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. 2018 Apr 9;13(4):e0195525. doi: 10.1371/journal.pone.0195525

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Fig 4 — (A) Receptor specificity of the CA/04, CA/04^+MAA, CA/04^+SNA, and CA/04^+Calu-3 viruses. °P < 0.01, *P < 0.05 in color, compared to the values for the wild-type CA/04 virus. °P < 0.01, *P < 0.05 in black, compared to the values for the CA/04^+Calu-3 virus. Biacore sensograms for CA/04, CA/04^+MAA, CA/04^+SNA, and CA/04^+Calu-3 binding with 6'SLN- (B) or 3'SLN-immobilized sensor surface (C). Purified and concentrated viruses serially diluted in HBS-P buffer in the presence of 5 mM zanamivir to a concentration range of 0.005–0.16 nM were applied over immobilized glycans. Binding level (RU) at the highest virus concentration (0.16 nM) is shown. Association rate (k_on) and dissociation rate (k_off) constants together with equilibrium association (K_A) and dissociation (K_D) constants (S2 Table) were calculated using BIAevaluation software 4.1.