Table 7. Correlation between the GC-corrected density of DNMs and various genomic variables.
| Individual correlations | Multiple regression | |||||
|---|---|---|---|---|---|---|
| Francioli | Wong | Jonsson | Francioli | Wong | Jonsson | |
| Male recombination rate | 0.092*** | 0.18*** | 0.15*** | 0.099*** | 0.15*** | |
| Female recombination rate | 0.10*** | 0.16*** | 0.074*** | 0.078** | 0.072** | |
| H3K4me1 | -0.006 | 0.015 | -0.028 | 0.13** | 0.12** | |
| H3K4me3 | -0.096*** | -0.12*** | -0.090** | -0.091** | -0.18*** | |
| H3K27me3 | -0.040 | -0.023 | -0.036 | |||
| H3K27ac | -0.047* | -0.037 | -0.044* | 0.11** | ||
| Transcription rate | -0.050* | -0.094*** | -0.029 | |||
| H3K4me1PB | -0.051* | -0.015 | -0.080*** | 0.055* | -0.071* | |
| H3K9me3PB | 0.022 | 0.004 | 0.032 | |||
| Nucleosome occupancy | 0.020 | 0.040 | -0.001 | |||
| DNAse hypersensitivity | -0.031 | -0.024 | -0.026 | |||
| Replication time | -0.090*** | -0.079*** | -0.10*** | -0.13*** | -0.087* | -0.14** |
| PC1 | -0.040 | -0.026 | -0.048* | |||
| PC2 | 0.14*** | 0.23*** | 0.15*** | |||
| PC3 | -0.012 | -0.010 | 0.000 | |||
| PC4 | 0.025 | -0.005 | 0.084*** | |||
Also given are standardised slopes from a multiple regression with forward parameter selection (p<0.05 for inclusion). The density of DNMs was corrected for GC-content by regressing DNM density against GC-content and the squared GC-content and taking the residuals.
* p < 0.05
** p < 0.01
*** p < 0.001