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. Author manuscript; available in PMC: 2018 Jul 22.
Published in final edited form as: Nat Chem. 2018 Jan 22;10(3):318–324. doi: 10.1038/nchem.2927

Figure 4. Location of mutations in evolved ArMs.

Figure 4

a , side and b, top views of POP ribbon model with spheres showing the location of mutations in variants 0-ZA4 (gray), 1-NAGS (red), 2-NSIA (orange), and 3-VRVH (blue). Mutations with greatest impact on enantioselectivity are labeled. Residues modified via carbene insertion (vide infra) are also shown as spheres (purple: W175; green: W142).