. Author manuscript; available in PMC: 2018 Jul 22.

Published in final edited form as: Nat Chem. 2018 Jan 22;10(3):318–324. doi: 10.1038/nchem.2927

Table 1.

Additional products from 3-VRVH catalyzed (1 mol%) cyclopropanation using conditions from Figure 1a with %yield and (e.e.) shown.



Entry	R¹	R²	R³	Yield (%)	e.e. (%)
1	MeO	MeO	Me	25	86
2	H	MeO	Et	43	94
3	Cl	MeO	Me	46	86
4	H	H	Me	66	88
5	H	Cl	Me	52	90
6	H	Br	Me	54	92

Reactions conducted as shown in Figure 1A using 22 mM styrene, 4.4 mM diazo, and 1 mol% ArM in 10% v/v THF/50 mM PIPES (pH 7.4) containing 1.75 M NaBr at 4 °C for 4 hours. Yields and e.e. were determined by HPLC using an internal standard (1,3,5-trimethoxybenzene).