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. Author manuscript; available in PMC: 2018 Apr 9.
Published in final edited form as: J Drug Des Res. 2017 Jun 29;4(6):1055.

Figure 2.

Figure 2

Increased levels of DNMT1 binding at Bdnf-ix, Rein, and Gad1 promoter regions in the frontal cortex of PRS mice are reduced by treatment with clozapine (5mg/kg twice a day for 5 days) but not haloperidol (1mg/kg twice a day for 5 days). The animals (PND 75) were tested on Day 6, 18hr after the last injection of neuroleptic. Data are expressed as mean +/− SEM of 5 animals per group and analyzed with one-way ANOVA followed by Student Newman-Keuls multiple comparisons. ANOVA for Bdnf-ix (7.13, P <0.001), Rein (F3,20 5.4, p <0.01), Gad1 (F3,20 5.8, p <0.001); (data from Dong et al[15]).