Figure 5.

(A) Testosterone and (B) dihydrotestosterone levels in prostate tissues of transgenic adenocarcinoma of the mouse prostate (TRAMP) mice after 1‐month oral administration of curcumin. Each bar represents mean ± SEM for 4 untreated and 8 curcumin‐treated TRAMP mice, respectively. Statistical significance (**P < .01) was obtained for curcumin treatment compared with the control. (C) Immunohistochemistry showing Aldo‐Keto reductase 1C2 (AKR1C2) proteins were expressed in prostate epithelial cells of TRAMP mice. (D) Expression of AKR1C2 in individual prostate tissue of curcumin‐treated TRAMP mice compared with control