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. 2018 Mar 23;109(4):1044–1054. doi: 10.1111/cas.13538

Figure 5.

Figure 5

miR‐20a is involved in chemoresistance of gastric cancer (GC) cells. A, IC50 values of SGC7901 cells to vincristine (VCR), Adriamycin (ADR), 5‐fluorouracil (5‐FU) and cisplatin (CDDP) calculated from MTT assays after transfection with miR‐20a mimic or control. *P < .05, **P < .01. B, IC50 values of SGC7901/ADR cells to VCR, ADR, 5‐FU and CDDP calculated from MTT assays after transfection with miR‐20a inhibitor or control. *P < .05, **P < .01. C, IC50 values of SGC7901/VCR cells to VCR, ADR, 5‐FU, and CDDP calculated from MTT assays after transfection with miR‐20a inhibitor or control. *P < .05. D, Apoptotic rates of cells treated with 5‐FU for 24 h were measured by flow cytometry. *P < .05, **P < .01. E, Western blotting of LRIG1 in SGC7901 cells co‐transfected with miR‐20a mimic and LRIG1 plasmid. β‐actin was used as an internal control. F, IC50 values of SGC7901 cells to VCR, ADR, 5‐FU and CDDP calculated from MTT assays after co‐transfection with miR‐20a mimic and leucine‐rich repeats and immunoglobulin‐like domains 1 (LRIG1) plasmid. *P < .05