Table 2.

Correlations between the density of tumor‐infiltrating lymphocytes (TILs) in pretreatment biopsy specimens and response to neoadjuvant treatment in 64 patients with locally advanced rectal cancer

	Pathological responsea			Downstaging of primary tumor
	Non‐respondersb	Respondersc	P‐value	Negative	Positive	P‐value
Density of CD8+ TILs
<8	13	2	<.001	13	2	.21
≥8	3	12		9	6
Density of CD4+ TILs
<4.6	8	5	.480	10	3	1.00
≥4.6	8	9		12	5
Density of T‐bet+ TILs
<2.3	9	6	.720	11	4	1.00
≥2.3	7	8		11	4
Density of GATA3+ TILs
<0.75	10	2	.011	10	2	.42
≥0.75	6	12		12	6
Density of RORγT+TILs
<1.2	7	6	1.000	10	3	1.00
≥1.2	9	8		12	5
Density of Foxp3+ TILs
<13.6	10	5	.270	10	5	.68
≥13.6	6	9		12	3

Foxp3, forkhead box P3; GATA3, GATA‐binding protein 3; RORγT, RAR‐related orphan receptor‐γT; T‐bet, t‐box expressed in T cells.

^aAccording to definitions in the Japanese Classification of Colorectal Carcinoma (8th edition).

^bGrade 0‐1a.

^cGrade 1b‐3.