Table 5.
Correlations between the density of tumor‐infiltrating lymphocytes (TILs) in post‐treatment resected specimens and response to treatment in the neoadjuvant chemotherapy cohort of patients with locally advanced rectal cancer (n = 33)
| Pathological responsea | Downstaging of primary tumor | |||||
|---|---|---|---|---|---|---|
| Non‐respondersb | Respondersc | P‐value | Negative | Positive | P‐value | |
| Density of CD8+ TILs | ||||||
| <13.4 | 18 | 3 | <.001 | 18 | 3 | .390 |
| ≥13.4 | 3 | 9 | 8 | 3 | ||
| Density of CD4+ TILs | ||||||
| <8.2 | 10 | 4 | .490 | 12 | 2 | .670 |
| ≥8.2 | 11 | 8 | 14 | 4 | ||
| Density of T‐bet+ TILs | ||||||
| <8 | 14 | 8 | 1.000 | 20 | 2 | .060 |
| ≥8 | 7 | 4 | 6 | 4 | ||
| Density of GATA3+ TILs | ||||||
| <0.5 | 7 | 4 | 1.000 | 8 | 2 | 1.000 |
| ≥0.5 | 14 | 8 | 18 | 4 | ||
| Density of RORγT+ TILs | ||||||
| <1.3 | 12 | 7 | 1.000 | 17 | 2 | .190 |
| ≥1.3 | 9 | 5 | 9 | 4 | ||
| Density of Foxp3+ TILs | ||||||
| <5.7 | 10 | 4 | .490 | 14 | 0 | .024 |
| ≥5.7 | 11 | 8 | 12 | 6 | ||
Foxp3, forkhead box P3; GATA3, GATA‐binding protein 3; RORγT, RAR‐related orphan receptor‐γT; T‐bet, t‐box expressed in T cells.
a
According to definitions in the Japanese Classification of Colorectal Carcinoma (8th edition).
b
Grade 0‐1a.
c
Grade 1b‐3.