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Schematic illustration of FBW7 regulating chemosensitivity of glioma cells to temozolomide (TMZ). On one hand, by regulating Aurora B, FBW7 inhibits G2/M transition and results in G2/M arrest and subsequent apoptosis. On the other hand, by regulating Mcl1, FBW7 enhances apoptotic cell death. (Green indicates tumor survival strategy and red indicates TMZ cytotoxic effect)
