Skip to main content
. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Infect Genet Evol. 2018 Feb 19;60:109–116. doi: 10.1016/j.meegid.2018.02.022

Figure 1. Overall structure of the cag PAI (A) and CagA protein (B) in H. pylori strain P12.

Figure 1

A. Structure of the cag PAI region (~37 kb). The region comprises 28 genes that encode components of the cag-T4SS, including the CagA protein effector.

B. Structure of the CagA protein (1,214 amino acid residues). The N-terminal part of CagA harbors a putative β-integrin-binding region. The C-terminal region comprises the EPIYA region, which contains EPIYA ABCC motifs and three MKI/CM/CRPIA motifs, regions that bind to the secretion chaperone CagF and contain the C-terminal secretion signal.