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Hypothesis of the mechanism for gadolinium deposition via the glymphatic system. Introducing our hypothesis for gadolinium deposition. Compared with gadolinium-based contrast medium (GBCM) in the systemic circulation, GBCM distributed into the cerebrospinal fluid cavity via glymphatic system can remain in brain tissue for a long time. The authors of this review speculate that the glymphatic system may be involved in the tissue deposition of gadolinium.
