Table 1.

The three diffusivity values calculated by each method and reader

	Well-to-moderately differentiated HCC	Poorly differentiated HCC	P value
Method A, reader 1
D (×10−3 mm2/s)	1.05 (1.03, 0.72–1.97)	1.00 (0.95, 0.81–1.37)	0.3649
D* (×10−3 mm2/s)	551.0 (62.5, 5.0–3553.4)	303.1 (46.4, 5.0–3410.3)	0.3990
f (%)	12.7 (11.5, 0–31.1)	12.8 (11.3, 5.9–22.1)	0.6864
reader 2
D (×10−3 mm2/s)	1.04 (1.04, 0.58–1.97)	0.97 (0.92, 0.76–1.34)	0.2399
D* (×10−3 mm2/s)	538.6 (44.6, 5.0–4181.4)	325.0 (47.2, 5.3–3522.7)	0.7672
f (%)	12.8 (13.2, 0–32.3)	12.9 (12.5, 5.0–24.7)	0.9072
Method B, reader 1
D (×10−3 mm2/s)	0.95 (0.96, 0.70–1.28)	0.72 (0.71, 0.55–0.97)	<0.0001†
D* (×10−3 mm2/s)	228.5 (30.7, 5.0–3904.2)	19.0 (15.7, 5.0–77.9)	0.0211†
f (%)	16.5 (15.8, 0–53.8)	23.6 (23.4, 8.9–50.2)	0.0232†
reader 2
D (×10−3 mm2/s)	0.95 (0.97, 0.65–1.34)	0.75 (0.76, 0.54–0.97)	0.0005†
D* (×10−3 mm2/s)	323.2 (31.4, 5.0–2642.7)	22.6 (13.9, 5.1–78.5)	0.0366†
f (%)	15.7 (15.9, 0–53.3)	21.7 (18.7, 8.2–50.7)	0.0834
Method C, reader 1
D (×10−3 mm2/s)	0.95 (0.96, 0.70–1.28)	0.72 (0.71, 0.55–0.97)	<0.0001†
D* (×10−3 mm2/s)	204.6 (15.8, 0–2214.1)	7.88 (6.47, 5.0–12.3)	0.0004†
f (%)	18.3 (17.9, 0–55.7)	29.2 (31.6, 9.7–54.3)	0.0016††
reader 2
D (×10−3 mm2/s)	0.95 (0.97, 0.65–1.34)	0.75 (0.76, 0.54–0.97)	0.0005†
D* (×10−3 mm2/s)	155.1 (14.1, 0–2292.9)	8.71 (7.96, 5.0–14.6)	0.0192†
f (%)	17.8 (16.7, 0–55.7)	25.9 (24.6, 11.5–54.5)	0.0279††

Statistical analyses were performed using the Wilcoxon test. Data are presented as the mean (median, range). HCC, hepatocellular carcinoma; D, true diffusion coefficient; D^*, diffusion coefficient for perfusion; f, perfusion fraction.

^†, The D and D^* values of poorly differentiated HCCs were lower than were those of well-to-moderately differentiated HCCs (P < 0.05);

^††, The f value of poorly differentiated HCCs was higher than was that of well-to-moderately differentiated HCCs (P < 0.05).