Table 3.
Breast Cancer Mortality | CVD Mortality | Other Cause Mortality | |||||||
---|---|---|---|---|---|---|---|---|---|
Deaths | HR | 95 % CI | Deaths | HR | 95 % CI | Deaths | HR | 95% CI | |
Unadjusted | |||||||||
| |||||||||
High Waist Circumference | |||||||||
| |||||||||
No | 339 | Ref | 234 | Ref | 575 | Ref | |||
| |||||||||
Yes | 279 | 1.23 | 1.05–1.44 | 224 | 1.46 | 1.22–1.76 | 528 | 1.41 | 1.25–1.59 |
| |||||||||
History of High Cholesterol | |||||||||
| |||||||||
No | 496 | Ref | 342 | Ref | 883 | Ref | |||
| |||||||||
Yes | 75 | 1.01 | 0.79–1.28 | 90 | 1.77 | 1.40–2.23 | 149 | 1.14 | 0.96–1.36 |
| |||||||||
History of Diabetes | |||||||||
| |||||||||
No | 589 | Ref | 419 | Ref | 1,015 | Ref | |||
| |||||||||
Yes | 30 | 1.04 | 0.72–1.50 | 39 | 1.92 | 1.38–2.66 | 88 | 1.80 | 1.44–2.23 |
| |||||||||
High Blood Pressure | |||||||||
| |||||||||
No | 360 | Ref | 178 | Ref | 559 | Ref | |||
| |||||||||
Yes | 259 | 1.09 | 0.93–1.27 | 279 | 2.40 | 1.99–2.90 | 543 | 1.49 | 1.33–1.68 |
| |||||||||
Cardiometabolic Abnormalities | |||||||||
| |||||||||
None | 181 | Ref | 68 | Ref | 254 | Ref | |||
| |||||||||
1 – 2 Abnormalities | 357 | 1.18 | 0.99–1.41 | 313 | 2.83 | 2.17–3.67 | 693 | 1.68 | 1.45–1.94 |
| |||||||||
3 – 4 Abnormalities | 32 | 1.23 | 0.84–1.79 | 48 | 5.13 | 3.54–7.42 | 84 | 2.42 | 1.89–3.09 |
| |||||||||
p-trend | 0.068 | <.001 | <.001 | ||||||
| |||||||||
Adjusted* | |||||||||
| |||||||||
High Waist Circumference | |||||||||
| |||||||||
No | 339 | Ref | 234 | Ref | 575 | Ref | |||
| |||||||||
Yes | 279 | 1.19 | 0.93–1.52 | 224 | 1.28 | 1.05–1.57 | 528 | 1.32 | 1.16–1.49 |
| |||||||||
History of High Cholesterol | |||||||||
| |||||||||
No | 496 | Ref | 342 | Ref | 883 | Ref | |||
| |||||||||
Yes | 75 | 0.96 | 0.75–1.22 | 90 | 1.30 | 1.02–1.65 | 149 | 0.94 | 0.79–1.12 |
| |||||||||
History of Diabetes | |||||||||
| |||||||||
No | 589 | Ref | 419 | Ref | 1,015 | Ref | |||
| |||||||||
Yes | 30 | 0.81 | 0.54–1.21 | 39 | 1.52 | 1.07–2.16 | 88 | 1.58 | 1.25–1.98 |
| |||||||||
High Blood Pressure | |||||||||
| |||||||||
No | 360 | Ref | 178 | Ref | 559 | Ref | |||
| |||||||||
Yes | 259 | 0.95 | 0.80–1.13 | 279 | 1.67 | 1.37–2.04 | 543 | 1.15 | 1.02–1.31 |
| |||||||||
Cardiometabolic Abnormalities | |||||||||
| |||||||||
None | 181 | Ref | 68 | Ref | 254 | Ref | |||
| |||||||||
1 – 2 Abnormalities | 357 | 1.05 | 0.86–1.29 | 313 | 2.06 | 1.58–2.69 | 693 | 1.39 | 1.20–1.61 |
| |||||||||
3 – 4 Abnormalities | 32 | 0.97 | 0.65–1.46 | 48 | 3.29 | 2.25–4.82 | 84 | 1.90 | 1.49–2.44 |
| |||||||||
p-trend | 0.857 | <.001 | <.001 |
Models adjusted for age group, WHI trial (OS vs CT), and covariates that modified the HR for 3–4 cardiometabolic abnormalities by 5% or more. In addition, individual cardiometabolic abnormalities were adjusted for one another. For breast cancer mortality, models adjusted for age group, WHI trial, race, alcohol intake, episodes of moderate to strenuous physical activity, and BMI. For CVD mortality, models adjusted for age group, WHI trial, alcohol intake, episodes of moderate to strenuous physical activity, and hormone therapy use. For other cause mortality, models adjusted for age group and WHI trial.