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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Mol Genet Metab. 2018 Feb 23;123(4):449–462. doi: 10.1016/j.ymgme.2018.02.013

Figure 6. Antioxidant drug effects on downregulated KEGG pathways in gas-1(fc21) adult worms.

Figure 6

Transcriptome expression changes in the KEGG biochemical pathway that were significantly downregulated in gas-1(fc21) relative to wild-type (N2 Bristol) worms (first comparison, p<0.05) were evaluated in gas-1(fc21) mitochondrial complex I mutant nematodes treated for 24 hours during early adulthood with one of (A) six water-soluble drugs relative to S. basal control or (B) lipophilic vitamin E relative to ethanol control. Wild-type worms (N2 Bristol) were treated only with buffer control. Each bar indicates comparative pathway changes in second group listed as compared to first. Enrichment score conveys degree to which upregulated KEGG biochemical pathways in gas-1(fc21) relative to N2 control were normalized by each treatment in gas-1(fc21) worms.