Table 1.

Dose Escalation Schedule (standard 3+3 design) with Dose Limiting Toxicities

Dose Level	Gemcitabine (mg/m2)	Erlotinib (mg QD)	Dasatinib (mg QD)	Cycle 1 (28-days) Toxicity
Level -1	800	100	50	6 patients; 1/6 with DLTa
Level 0 (starting)	800	100	70	6 patients; 1/6 with DLTb
Level 1	800	100	100	7 patients (6 evaluable); 1/6 with DLTc
Level 2	1000	100	100	Not Evaluated
Level 3	1000	100	140	Not Evaluated

^aGrade 3 dyspnea;

^bGrade 3 nausea and vomiting;

^cGrade 3 elevated AST

QD: once daily; AST: aspartate aminotransferase