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Model of F. nucleatum infection-triggered inflammatory responses in gingival epithelial cells during healthy (dotted line) or diseased status (solid line). Pathogens and danger signals (DS) such as ATP activate the NLRP3 inflammasome, which is enhanced by NLRX1. Bacteria under non-pathogenic conditions can also stimulate NF-κB activation, which is dampened by NLRX1.
