. Author manuscript; available in PMC: 2019 May 1.

Published in final edited form as: Bioorg Med Chem. 2018 Feb 10;26(8):1547–1559. doi: 10.1016/j.bmc.2018.01.032

Table 2.

Structure-activity trends in a family of substituted phthalimidines.

compound	Clog D	% TNF-α^a	% nitrite^a
25	3.30	85	N/A^b
13	2.88	52	N/A^b
12	3.51	58	62
10	4.25	55	52
17	3.63	77	55
18	4.16	72	35
24	4.58	96	11.5

Analyte % are represented as average % of analyte relative to control samples. Raw data absorbed from Table 1.

Data was not available as the levels in the control media (i.e. DMSO + LPS) were lower than the lowest level on the nitrite values on the standard curve.