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. 2018 Feb 1;19(4):e44993. doi: 10.15252/embr.201744993

Figure EV1. Genomic localisation of ZBTB2 in mouse embryonic stem cells in vivo (related to Fig 1).

Figure EV1

  1. Comparison of the amino acid sequences of the zinc finger domains of ZBTB2 and the evolutionarily conserved methyl‐CpG‐binding zinc fingers of KAISO and KAISO‐like proteins.
  2. Matrix of the percentage similarity between each of the zinc finger domains depicted in (A). (M)ZF = (methyl)zinc finger.
  3. Sequence logo of a recently reported ZBTB2‐binding motif 16 and its occurrence in the called ZBTB2 ChIP‐seq peaks in ESCs and a background consisting of all mouse CGIs.
  4. The number of CpG dinucleotides counted in the sequences of the ZBTB2 ChIP‐seq peaks in ESCs and in a set of random promoters (n = 4,072) of the same average length (*P < 2.2e‐16, Welch t‐test). Box: median (central line), first and third quartile (box limits); whiskers: 1.5 × interquartile range.
  5. Heat map showing the ChIP‐seq read density (normalised on RPKM) for ZBTB2, H3K4me3 43 and H3K27ac 44 in ESCs, centred on all mouse CGIs.