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. 2018 Apr 10;4:16. doi: 10.1038/s41421-018-0015-4

Fig. 1. T-cell homeostasis and apoptosis in HCV-infected patients versus age-matched HS.

Fig. 1

a Naive CD4 T-cell loss in HCV patients vs. age-matched HS. PBMCs isolated from HCV-infected patients and HS were analyzed using flow cytometry for T-cell homeostasis. Representative dot plots and summary data of the flow cytometry for the percentages of total CD4+, CD45RA+CD4+ (naive), and CD45RA−CD4+ (memory) T-cell frequencies in PBMCs from HCV patients and HS are shown. Each symbol represents one particular subject; the mean ± SE and P value of the statistical analysis are shown, NS=no significance. b, c Susceptibility of T cells to spontaneous apoptosis and death in HCV patients vs. HS. Naive and memory CD4 T cells were purified from PBMCs of the subjects, cultured in vitro without stimulation for 0, 2, and 4 days, followed by flow cytometric analysis of AV and 7AAD expression. Representative dot plots for the cell purity, gating strategy, and summary data for the percentages of survival cells as well as apoptotic cells are shown. n=number of subjects studied in each group. NS=no significance. P value with significant changes are shown