Fig. 1.

The four-generation XLID pedigree and haplotype analysis results on Xq24. The disease-linked haplotype is depicted in black. Haplotypes are indicated with X-chromosome STR markers. The proximal boundary is determined by a recombination event in individual III-3 between DXS8055 and DXS424. The distal border is determined by both a recombination event in individual IV-5 and a historical recombination in IV-7 and IV-8 that was already present in III-12 between DXS8067 and DXS8059. An arrow indicates the location of the CXorf56 gene. Black symbols represent XLID impaired individuals, open symbols represent unaffected individuals, dotted symbols represent unaffected carriers, diagonal slash means deceased