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. 2018 Apr 3;9:297. doi: 10.3389/fphar.2018.00297

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Copyright © 2018 Ding, Wang, Fang, Xu, Fan, Tian, Zhai, Lu, Qi, Wei, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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D-dencichine has no direct effects on the proliferation and differentiation of megakaryocytes in vitro. (A,B) Viability of M07e and Meg-01 cells cultured with D-dencichine (12.5, 25, 50, 100, and 200 μM) for 24, 48, and 72 h as measured by CCK-8 assay. The data are from six independent assays with a single batch of cells. (C) Human cord blood-derived CD34⁺ cells were cultured with or without different concentrations of D-dencichine (25, 50, and 100 μM) together with rhSCF (20 ng/ml) and rhTPO (10 ng/ml) for 7, 10, and 13 days. The expressions of CD41α and CD42b in the cells treated with D-dencichine were analyzed through flow cytometry. (D) Histogram showing the percentage of CD41α⁺CD42b⁺ megakaryocytes for each group from the information in (C). ^#P < 0.05, ^##P < 0.01 vs. control group.