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. 2018 Apr 3;9:297. doi: 10.3389/fphar.2018.00297

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Copyright © 2018 Ding, Wang, Fang, Xu, Fan, Tian, Zhai, Lu, Qi, Wei, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Thrombopoietin-dependent signaling is enhanced with D-dencichine treatment in mouse liver, platelet, and spleen. (A–C) Western blots analysis of p-ERK1/2/ERK1/2, p-Akt/Akt proteins in liver, platelet, and spleen. Quantification analysis of TPO-dependent signaling proteins from the information in corresponding protein bands. (D) Effects of apoptosis-related protein expression with D-dencichine treatment in mouse platelet. The level of Bcl-2/Bax was determined by western blot. Quantification analysis of Bcl-2, Bax and Bcl-2/Bax expression ratio from the information in corresponding protein bands. ^##P < 0.01 vs. control group; ^∗P < 0.05, ^∗∗P < 0.01 vs. model group.