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. 2018 Apr 3;9:297. doi: 10.3389/fphar.2018.00297

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Copyright © 2018 Ding, Wang, Fang, Xu, Fan, Tian, Zhai, Lu, Qi, Wei, Sun and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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D-dencichine promotes the adherence, migration and PPF of megakaryocytes. (A) Western blot analysis of p-ERK1/2 and p-Akt in whole-cell lysates from Meg-01 cells after exposure to D-dencichine (100 μM) for the indicated times after starvation. Quantification analysis of p-ERK1/2/ERK1/2 and p-Akt/Akt from the information in corresponding protein bands. (B) Adherent Meg-01 treated with different concentrations of D-dencichine (25, 50, and 100 μM). (C) Representative images of migrated megakaryocytes after D-dencichine stimulation. Histogram of migrated megakaryocytes treated with different concentrations of D-dencichine. (D) The experimental process of fetal liver-derived megakaryocytes culture and purification. (E) Representative photographs of PPF after D-dencichine stimulation. Cytoskeleton actin (green) and the nucleus (blue) were stained. Quantification of PPF megakaryocytes treated with D-dencichine at different concentrations under an inverted microscope. ^#P < 0.05, ^##P < 0.01 vs. control group.