. Author manuscript; available in PMC: 2019 Feb 14.

Published in final edited form as: Clin Sci (Lond). 2018 Feb 2;132(3):313–325. doi: 10.1042/CS20171556

Table 3.

Disrupted splicing factor expression in senescent cardiomyocytes

	Early passage cardiomyocytes	Late passage cardiomyocytes
*AKAP17A*	1.011 (0.067)	0.970 (0.039)
*HNRNPA0*	1.025 (0.101)	0.917 (0.030)
*HNRNPA1*	1.021 (0.092)	1.063 (0.037)
*HNRNPA2B1*	1.026 (0.105)	1.254 (0.04)
*HNRNPD*	*1.035 (0.143)*	*1.732** (0.271)**
*HNRNPH3*	*1.033 (0.119)*	*1.579 (0.170)**
*HNRNPK*	*1.025 (0.108)*	*0.745 (0.037)**
*HNRNPM*	1.015 (0.079)	0.951 (0.028)
*HNRNPUL2*	1.041 (0.136)	1.031 (0.064)
*IMP3*	1.016 (0.081)	0.983 (0.035)
*LSM14A*	1.025 (0.102)	0.817 (0.025)
*LSM2*	1.009 (0.057)	0.927 (0.163)
*PNISR*	1.046 (0.143)	1.197 (0.052)
*SF3B1*	*0.996 (0.083)*	*1.201 (0.028)**
*SRSF1*	1.012 (0.071)	1.054 (0.098)
*SRSF2*	*1.006 (0.047)*	*0.851 (0.022)**
*SRSF3*	1.015 (0.079)	1.181 (0.155)
*SRSF6*	1.014 (0.075)	1.265 (0.242)
*TRA2B*	*1.049 (0.146)*	*0.634 (0.086)**
*SRSF7*	*1.015 (0.083)*	*0.668 (0.089)**

The expression profiles of transcripts encoding splicing regulatory factors in early and late passage cardiomyocytes are given below. Quantifications refer to the level of each splicing factor for each gene, normalised to the geometric mean of the level of each gene in early passage cells. The results are expressed as the mean of six independent experiments. Statistical significance is indicated by stars, with * = 0.05, ** = 0.001 and *** = <0.0001. Figures in parentheses refer to the S.E.M. Transcripts significantly altered in senescent cardiomyocytes are indicated in bold italic type.