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. Author manuscript; available in PMC: 2018 May 31.
Published in final edited form as: J Am Chem Soc. 2017 May 17;139(21):7188–7191. doi: 10.1021/jacs.7b03879

Figure 2.

Figure 2

Carolacton analogs elicit a range of phenotypic responses. (A) C3 inhibits biofilm formation with an MBIC50 of 63 μM, “B” = Blank wells; “C” = S. mutans control. (B) Confocal microscopy highlights the effect of C1 and D2 on the growth of S. mutans biofilm at 500 μM (top, field view; bottom, 4× zoom). (C) Carolacton and D4 (top, field view; bottom, 16× zoom) display similar phenotypes at 500 nM. White circles indicate spherical cell morphology and ovals highlight chains of cells. See Figures S3 and S4 for additional representative images.