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. 2018 Apr 10;19:58. doi: 10.1186/s12931-018-0766-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 12 — Nrf2, HO-1 and GCLc mRNA expression in lung tissue of Control, Crocin, COPD and COPD plus crocin (CO + CR) rats. *P < 0.05,***P < 0.01 vs. Control rats. ^††P < 0.01, ^†††P < 0.05 vs. the COPD group. All the groups were statistically compared by ANOVA followed by Tukey’s multiple comparison. Data are expressed as mean ± SEM