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. 2018 Apr 3;9:324. doi: 10.3389/fphys.2018.00324

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Copyright © 2018 Ruan, Ren, Zhang, Zhu, Xu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QSYQ improved loss of organization of myocardial fibers in TAC mice. Representative photographs of sections of left ventricles stained with anti-actinin2 antibody with a secondary antibody conjugated to Cy3. Sections were obtained from the Sham + NS, Sham + QSYQ, TAC + NS, and TAC + QSYQ groups 8 weeks after TAC. The Sham + NS group showed ordered myocardial fibers. By contrast, hearts from TAC mice showed disrupted myocardial fibers. QSYQ prevented loss of organization of myocardial fibers in TAC mice.