Fig. 2.

CTHRC1 inhibits adhesion and promotes NSCLC cell migration and invasion of in vitro and metastasis in vivo. a, d CTHRC1 overexpression inhibited cell adhesion; CTHRC1 knockdown increased cell adhesion; (b-f) Transwell assay results indicated that ectopic overexpression of CTHRC1 promoted cell invasion; knockdown of endogenous CTHRC1 inhibited cell invasion. Migratory cells were stained with HE and qualitatively assessed, as summarized in the bar graphs. g-j A wound assay indicated CTHRC1 overexpression increased tumour cell migration; CTHRC1 knockdown inhibited tumour cell migration. Migration distances were measured and are summarized in the bar graphs; *p < 0.05 and **p < 0.01