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. 2018 Apr 10;18:400. doi: 10.1186/s12885-018-4317-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The regulation of CTHRC1 on adhesion, migration, invasion and metastasis of tumor cells was mediated by MMP7 and MMP9. a Tumour cell adhesion ability decreased in CTHRC1-overexpressing cells. This decreased adhesion ability was elevated when either MMP7 or MMP9 was knocked down. b, c HE staining of cells invading through the Transwell gel demonstrated increased tumour cell invasion accompanying the ectopic overexpression of CTHRC1, which was inhibited by knocking down either MMP7 or MMP9. d-f A wound assay showing increased migration distance accompanying CTHRC1 overexpression. Knocking down either MMP7 or MMP9 inhibited the increased migration distance mediated by CTHRC1. *p < 0.05 and **p < 0.01