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. 2018 Apr 10;13:54. doi: 10.1186/s13023-018-0798-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Enlarged lysosomes and lipid accumulation in NCL patient NSCs. Increased LysoTracker dye staining (a) indicates enlarged lysosomes and a strong Nile red staining (b) indicates cytoplasmic lipid droplet accumulation in NCL NSCs compared to the WT control cells. Representative image of LysoTracker dye and Nile red staining were shown with 40X objective lens. Quantification of the acidic compartment (c) revealed significantly enlarged lysosomes in NCL NSCs and quantification of the cytoplasmic lipid droplet accumulation (d) was found significantly increased in NCL NSCs. Data are displayed as mean ± SD. ** P < 0.01 vs. WT control