Table 2.
Top-ranked biological processes enriched within transcripts significantly up-regulated in VAD versus control mice (FDR < 0.05 by LPE t -test)
| Term | Category | No. of of genes | % of genes | P -value |
|---|---|---|---|---|
| BP00107: Cytokine and chemokine mediated signaling pathway | PANTHER_BP_ALL | 17 | 17.2 | 2.55E-14 |
| BP00148: Immunity and defense | PANTHER_BP_ALL | 33 | 33.3 | 2.76E-13 |
| GO:0006955: Immune response | GOTERM_BP_FAT | 17 | 17.2 | 7.43E-10 |
| BP00288: Granulocyte-mediated immunity | PANTHER_BP_ALL | 9 | 9.1 | 1.58E-09 |
| GO:0006935: Chemotaxis | GOTERM_BP_FAT | 10 | 10.1 | 2.86E-09 |
| GO:0042330: Taxis | GOTERM_BP_FAT | 10 | 10.1 | 2.86E-09 |
| BP00122: Ligand-mediated signaling | PANTHER_BP_ALL | 14 | 14.1 | 1.60E-08 |
| GO:0009611: Response to wounding | GOTERM_BP_FAT | 13 | 13.1 | 1.08E-07 |
| GO:0006954: Inflammatory response | GOTERM_BP_FAT | 11 | 11.1 | 1.38E-07 |
| GO:0007626: Locomotory behavior | GOTERM_BP_FAT | 10 | 10.1 | 2.44E-06 |
| BP00155: Macrophage-mediated immunity | PANTHER_BP_ALL | 8 | 8.1 | 3.90E-06 |
| GO:0031424: Keratinization | GOTERM_BP_FAT | 5 | 5.1 | 1.01E-05 |
| GO:0006952: Defense response | GOTERM_BP_FAT | 12 | 12.1 | 1.07E-05 |
| BP00255: Cytokine/chemokine mediated immunity | PANTHER_BP_ALL | 7 | 7.1 | 1.26E-05 |
| GO:0006953: Acute-phase response | GOTERM_BP_FAT | 5 | 5.1 | 1.34E-05 |
| GO:0007610: Behavior | GOTERM_BP_FAT | 11 | 11.1 | 2.69E-05 |
| GO:0030216: Keratinocyte differentiation | GOTERM_BP_FAT | 5 | 5.1 | 8.92E-05 |
| GO:0009913: Epidermal cell differentiation | GOTERM_BP_FAT | 5 | 5.1 | 1.13E-04 |
| BP00274: Cell communication | PANTHER_BP_ALL | 16 | 16.2 | 2.57E-04 |
| GO:0030595: Leukocyte chemotaxis | GOTERM_BP_FAT | 4 | 4 | 3.08E-04 |
| GO:0060326: Cell chemotaxis | GOTERM_BP_FAT | 4 | 4 | 3.08E-04 |
| GO:0008544: Epidermis development | GOTERM_BP_FAT | 6 | 6.1 | 3.72E-04 |
| GO:0007398: Ectoderm development | GOTERM_BP_FAT | 6 | 6.1 | 4.95E-04 |
| GO:0002526: Acute inflammatory response | GOTERM_BP_FAT | 5 | 5.1 | 6.75E-04 |
| BP00103: Cell surface receptor mediated signal transduction | PANTHER_BP_ALL | 23 | 23.2 | 7.09E-04 |
| BP00156: Interferon-mediated immunity | PANTHER_BP_ALL | 5 | 5.1 | 1.14E-03 |
| GO:0050900: Leukocyte migration | GOTERM_BP_FAT | 4 | 4 | 1.23E-03 |
| BP00071: Proteolysis | PANTHER_BP_ALL | 13 | 13.1 | 2.95E-03 |
| BP00287: Cell motility | PANTHER_BP_ALL | 7 | 7.1 | 4.38E-03 |