Fig. 1.

Immune signaling molecules are expressed by glioma cells in vivo. (A) Microarray analysis of SYK, LYN, PLCG2, and SLP76 in NHAs, normal brain (Brain), glioblastoma (GBM), secondary glioblastoma (2ary-GBM), lower-grade astrocytoma (Astro), and oligodendrogliomas (Oligo) using Genedata Expressionist analyst software. (B) Representative IHC staining of GBM samples for SYK, LYN, and PLCG2; n > 15. (C) Tumor score of GBM samples stained for SYK, LYN, and PLCG2. (D) SYK expression in glioma mouse models (GFAP tvaPDGF ARF−/−; GFAP Cre+ NF1−/+ p53−/f PTEN +/f; S100b-v-ErbB; p53−/−). (E) SYK expression in 2 orthotopic glioma mouse models (U87MG-luc in HSD nude; GL261-L2G in C57BL/6J). (F) SYK expression of pilocytic astrocytoma n = 16 and (G) tumor score.