Table 1.

Demographic, clinical, and neuropathological data of subjects with and without diabetes mellitus (n = 1,037)

Variables	No Diabetes n = 758	Diabetes n = 279	p
Demographics, clinical variables, APOE genotyping
Age (y), mean (SD)*	74.7 (11.7)	73.5 (10.9)	0.16
Female, n (%)#	388 (51.2)	153 (54.8)	0.30
Education (y), mean (SD)*	4.1 (3.6)	4.2 (3.7)	0.58
Race, n (%)‡			0.67
White	456 (60.2)	172 (61.7)
Black	157 (20.7)	53 (19.0)
Admixed	129 (17.0)	51 (18.3)
Asian	16 (2.1)	3 (1.1)
Socioeconomic class, n (%)#			0.16
High	235 (31.0)	83 (29.8)
Middle	346 (45.7)	144 (51.6)
Low	176 (23.2)	52 (18.6)
Daily contact with the informant, n (%)#	536 (70.7)	194 (69.5)	0.71
Hypertension, n (%)#	456 (60.2)	224 (80.3)	<0.0001
Dyslipidemia, n (%)#	43 (5.7)	50 (17.9)	<0.0001
Physical inactivity, n (%)#	379 (50.0)	160 (57.3)	0.04
Smoking, n (%)#			0.08
Never	384 (50.7)	150 (53.8)
Current	208 (27.4)	58 (20.8)
Former	164 (21.6)	70 (25.1)
Alcohol use, n (%)#			0.42
Never	466 (61.5)	182 (65.2)
Current	178 (23.5)	55 (19.7)
Former	110 (14.5)	41 (14.7)
Coronary artery disease, n (%)#	151 (19.9)	74 (26.5)	0.02
Heart Failure, n (%)#	121 (16.0)	55 (19.7)	0.15
Stroke, n (%)#	109 (14.4)	58 (20.8)	0.01
CDR >0, n (%)#	311 (41.0)	121 (43.4)	0.53
APOE allele ε4, n (%)# §	108 (30.2)	37 (26.2)	0.38
Neuropathology			0.31
CERAD score, n (%)#
0	452 (59.6)	181 (64.9)
A	111 (14.7)	35 (12.5)
B	106 (14.0)	29 (10.4)
C	89 (11.7)	34 (12.2)
Braak-Braak stages, n (%)#			0.81
0	146 (19.4)	60 (21.6)
I	116 (15.4)	46 (16.6)
II	214 (28.4)	73 (26.3)
III	116 (15.4)	49 (17.6)
IV	73 (9.7)	21 (7.5)
V	41 (5.5)	14 (5.0)
VI	47 (6.2)	15 (5.4)

CDR, Clinical Dementia Rating; APOE, apolipoprotein E; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease; SD, standard deviation.

^*unpaired t-test;

^†Mann-Whitney test;

^#Chi-square test;

^‡Fisher’s exact test.

^§Data available for 524 participants.