Table 3.
Association of AD neuropathology with cognitive impairment, considering interaction terms between diabetes and AD neuropathology (ADNP) (n = 1,037)
| N with/without cognitive impairment | OR (95% CI) | p* | |
|---|---|---|---|
| Braak-Braak Score | <0.0001 | ||
| 0–II | 207/454 | 0.50 (0.35–0.72) | |
| III-IV | 128/131 | 0.86 (0.55–1.32) | |
| V-VI | 97/20 | 5.34 (2.72–10.49) | |
| CERAD | |||
| 0-A | 271/508 | 0.59 (0.41–0.83) | <0.0001 |
| B | 74/61 | 0.86 (0.51–1.44) | |
| C | 87/36 | 2.45 (1.39–4.30) |
*
p-value for the interaction between ADNP and diabetes. Multivariable ordinal logistic regression adjusted for age, sex, race, education, hypertension, dyslipidemia, physical inactivity, smoking, and alcohol use.