Table 7.
The comparison of biomarker levels between gram-positive and gram-negative sepsis.
| Parameter | Day 1 | Day 2 | Day 3 | Day 4 | P | ||||
|---|---|---|---|---|---|---|---|---|---|
| G+ | G− | G+ | G− | G+ | G− | G+ | G− | ||
| MCP-1 (pg/mL) | 576.40 (1188.61) | 685.84 (4291.12) | 505.33 (692.46) | 786.23 (1593.18) | 450.84 (742.37) | 715.29 (848.93) | 415.96 (438.42) | 745.97 (616.07) | n.s. |
| MIP-1β (pg/mL) | 43.49 (62.26) | 48.99 (75.74) | 43.03 (79.45) | 39.39 (67.09) | 39.11 (72.34) | 28.45 (65.29) | 37.78 (86.18) | 36.79 (47.61) | n.s. |
| IL-6 (pg/mL) | 47.74 (133.21) | 18.96 (399.91) | 20.98 (56.49) | 27.98 (202.13) | 11.28 (40.93) | 11.21 (295.56) | 2.65 (40.24) | 15.02 (41.50) | n.s. |
| IL-8 (pg/mL) | 80.54 (192.72) | 106.62 (150.94) | 60.14 (187.78) | 31.43 (89.09) | 65.83 (174.18) | 40.56 (107.72) | 63.23 (208.04) | 34.49 (98.74) | n.s. |
| IL-10 (pg/mL) | 6.32 (15.18) | 1.90 (47.42) | 1.90 (8.84) | 3.64 (6.48) | 1.90 (12.34) | 1.90 (15.91) | 1.90 (8.44) | 1.90 (3.94) | n.s. |
| HBP (ng/mL) | 236.33 (462.47) | 288.59 (894.53) | 122.42 (267.37) | 162.18 (532.89) | 111.85 (238.57) | 124.47 (232.94) | 82.94 (113.00) | 115.96 (388.1) | n.s. |
| sCD14 (mg/L) | 3.62 (1.34) | 3.89 (1.12) | 3.59 (1.48) | 4.11 (1.14) | 3.58 (1.39) | 3.82 (1.24) | 3.68 (2.24) | 3.28 (1.64) | n.s. |
| Cortisol (nmol/L) | 326.90 (290.20) | 442.80 (400.25) | 396.20∗ (421.4) | 662.00∗ (2038.60) | 423.20 (431.20) | 545.55 (538.2) | 452.60 (335.5) | 416.15 (381.50) | 0.048 |
Data are presented as median (quartile); n.s.: not significant; ∗P < 0.05: gram-positive (G+) versus gram-negative (G−) infection. The statistical difference-analyzed parameters in the groups were analyzed by the Mann–Whitney U test.