Table 8.
The comparison of biomarker levels among the groups based on the source of sepsis.
| Parameter | Day 1 | Day 2 | Day 3 | Day 4 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BM | IE | CAP | BM | IE | CAP | BM | IE | CAP | BM | IE | CAP | |
| MCP-1 (pg/mL) | 133.81,2 (149.0) | 542.41 (693.2) | 685.62 (1064.9) | 130.01,2 (158.5) | 624.51 (454.3) | 667.72 (509.3) | 154.11,2 (136.6) | 489.51 (274.4) | 581.52 (513.5) | 221.11,2 (216.9) | 471.81 (334.4) | 605.32 (378.9) |
| MIP-1β (pg/mL) | 25.0 (67.0) | 40.6 (56.7) | 23.1 (73.4) | 14.2 (63.7) | 29.7 (74.8) | 12.8 (36.2) | 16.4 (45.8) | 30.1 (82.4) | 13.8 (22.5) | 23.3 (73.9) | 26.9 (90.9) | 13.4 (26.4) |
| IL-6 (pg/mL) | 12.8 (46.5) | 22.1 (113.8) | 49.9 (191.9) | 1.61,2 (10.4) | 29.91 (76.3) | 18.42 (91.2) | 1.21,2 (6.9) | 29.91 (61.0) | 8.12 (96.0) | 1.2 (12.1) | 42.5 (92.1) | 1.2 (25.9) |
| IL-8 (pg/mL) | 13.1 (133.7) | 37.3 (157.4) | 47.1 (102.9) | 14.2 (169.6) | 34.7 (126.8) | 22.6 (43.5) | 32.3 (151.1) | 33.6 (191.1) | 34.4 (99.5) | 44.7 (130.9) | 52.4 (185.5) | 25.1 (34.0) |
| IL-10 (pg/mL) | 1.91,2 (0.0) | 11.91 (17.7) | 10.22 (6.6) | 1.91 (0.0) | 9.81 (14.4) | 1.9 (7.6) | 1.91 (0.0) | 5.21 (14.5) | 9.5 (13.3) | 1.92 (0.0) | 1.9 (7.2) | 12.52 (14.2) |
| HBP (ng/mL) | 110.11 (225.1) | 369.61 (826.3) | 96.7 (187.0) | 92.1 (165.4) | 189.5 (362.6) | 57.2 (140.4) | 66.8 (134.5) | 230.2 (457.0) | 102.5 (130.8) | 43.4 (77.1) | 111.3 (224.8) | 155.2 (332.8) |
| sCD14 (mg/L) | 3.02 (1.0) | 4.0 (1.3) | 4.52 (0.6) | 2.81,2 (0.6) | 4.21 (1.2) | 4.02 (1.1) | 2.61,2 (0.5) | 3.91 (0.8) | 3.72 (2.1) | 2.31,2 (1.5) | 4.01 (1.6) | 4.22 (2.9) |
| Cortisol (nmol/L) | 174.3 (146.9) | 556.2 (531.9) | 324.7 (555.8) | 95.11 (75.7) | 509.51 (450.8) | 290.6 (377.4) | 76.71,2 (88.7) | 528.71 (217.8) | 215.12 (329.3) | 111.31 (248.5) | 531.51,3 (143.3) | 220.63 (305.6) |
Data are presented as median (quartile); BM: bacterial meningitis; IE: infective endocarditis; CAP: community-acquired pneumonia; 1P < 0.05: BM versus IE; 2P < 0.05: BM versus CAP; 3P < 0.05: IE versus CAP. The statistical difference-analyzed parameters for multiple comparison were analyzed by the Kruskall-Wallis test.