Table 3.
Comparative mean analysis of serum enzymatic activities of GDH and LDH, concentration of glutathione, and the oxidative stress index of breast cancer (BCA) patients (N = 27) and control group (N = 27), Addis Ababa, Ethiopia, 2015–2017.
| Serum parameters | Control group | BCA patients | Mean diff. | P value | 95% CI |
|---|---|---|---|---|---|
| GDH (mU/l) | 3.15 ± 0.69 | 4.20 ± 0.72 | 1.04 | ≤0.001 | (0.8–1.3) |
| LDH (mU/l) | 30.4 ± 32.6 | 78.6 ± 113 | 48.2 | 0.036∗ | (3.4–92.9) |
| GSH (μM per μg of protein) | 20.9 ± 2.6 | 10.2 ± 2.9 | −10.7 | ≤0.001 | (4.3–6.0) |
| GSSG (μM per μg of protein | 0.2 ± 0.1 | 0.51 ± 0.2 | 0.31 | ≤0.001 | (0.8–1.2) |
| TOS (μmol H2O2 Eq/l) | 2.32 ± 1.0 | 2.75 ± 1.1 | 0.43 | ≤0.001 | (0.39–1.27) |
| TAC (mmol Trolox Eq/l) | 100.9 ± 29.8 | 83.5 ± 30.3 | −13.65 | 0.017∗ | (−24.7 to −2.6) |
| OSI (ratio of TOS/TAC∗100) | 2.3 ± 1.5 | 3.3 ± 1.7 | 1.0 | 0.006∗ | (0.32–1.67) |
| Total protein (μg/ml) | 59.7 ± 29.3 | 208 ± 11.8 | 148.22 | 0.001∗ | (143.56–152.87) |
∗The mean difference is significant at P value ≤ 0.05.