Table 4.
Comparative mean analysis of tissue enzymatic activities of GDH and LDH, concentration of glutathione, and the oxidative stress index of noncancerous tissues (N = 27) and cancerous tissues (N = 27), Addis Ababa, Ethiopia, 2015–2017.
| Tissue parameters | Normal tissue | Tumor tissue | Mean diff. | P value | 95% CI |
|---|---|---|---|---|---|
| GDH (mU/l) | 0.92 ± 0.73 | 1.40 ± 0.88 | 0.5 | 0.011∗ | (0.12–0.82) |
| LDH (mU/l) | 70.5 ± 10.7 | 111.7 ± 23.2 | 41.2 | 0.009∗ | (−7.5 to 89.9) |
| GSH (μM per μg of protein) | 14.9 ± 2.7 | 11.03 ± 2.0 | −3.87 | 0.029∗ | (−0.2 to 0.8) |
| GSSG (μM per μg of protein) | 0.21 ± 0.1 | 0.47 ± 0.3 | 0.26 | 0.003∗ | (0.09–0.02) |
| TOS (μmol H2O2 Eq/l) | 2.1 ± 0.9 | 3.5 ± 1.1 | 1.4 | ≤0.001 | (0.33–1.22) |
| TAC (mmol Trolox Eq/l) | 188.9 ± 26.7 | 161.6 ± 50.8 | −27.32 | 0.01∗ | (−47.42 to −7.2) |
| OSI (ratio of TOS/TAC∗100) | 1.1 ± 0.5 | 2.15 ± 1.8 | 1.05 | 0.002∗ | (0.3–1.22) |
| Total protein (μg/ml) | 149.4 ± 54.2 | 194.9 ± 27.4 | 45.5 | 0.001∗ | (34.7–56.4) |
∗The mean difference is significant at P value ≤ 0.05.