Table 5.
A one-way ANOVA (post hoc) analysis of serum and tissue parameters in control subjects and pathologically confirmed breast cancer patients participated from five hospitals of Addis Ababa, Ethiopia (N = 27), 2015–2017.
| Serum and tissue parameters of BCA | Sample | Stages of breast cancer patients | ||||
|---|---|---|---|---|---|---|
| Stage 0 (N = 5) | Stage I (N = 4) | Stage II (N = 7) | Stage III (N = 8) | Stage IV (N = 3) | ||
| GDH | S | 4.6 ± 0.4 | 4.1 ± 0.5 | 4.13 ± 0.91 | 4.2 ± 0.9 | 3.7 ± 0.45 |
| T | 0.7 ± 0.2a | 1.2 ± 0.6 | 1.24 ± 0.71 | 1.9 ± 1.1a | 1.78 ± 1.15 | |
| LDH | S | 77.7 ± 27.1 | 80.9 ± 38.7 | 138.7 ± 61.9 | 57.6 ± 5.4 | 90.0 ± 11.7 |
| T | 42.4 ± 4.1b | 63.8 ± 5.1b | 67.7 ± 3.1b | 131.3 ± 8.4b | 341.8 ± 41.4b | |
| GSH | S | 5.4 ± 2.4 | 5.9 ± 0.5 | 5.8 ± 1.8 | 7.0 ± 3.3 | 6.3 ± 0.6 |
| T | 1.0 ± 0.3 | 1.2 ± 0.5 | 2.0 ± 1.9 | 1.4 ± 1.5 | 1.5 ± 0.7 | |
| GSSG | S | 1.1 ± 0.5 | 1.2 ± 0.1 | 1.1 ± 0.4 | 1.4 ± 0.6 | 1.2 ± 0.1 |
| T | 0.3 ± 0.1 | 0.3 ± 0.04 | 0.2 ± 0.1 | 0.3 ± 0.1 | 0.2 ± 0.03 | |
| TOS | S | 1.4 ± 0.4c | 3.4 ± 1.3c | 2.4 ± 0.7 | 3.2 ± 1.16c | 2.8 ± 0.6c |
| T | 3.2 ± 0.3 | 2.3 ± 0.4 | 3.3 ± 1.6 | 2.5 ± 1.2 | 2.4 ± 0.8 | |
| TAC | S | 0.90 ± 0.29 | 0.84 ± 0.14 | 0.87 ± 0.21 | 0.90 ± 0.34 | 0.77 ± 0.47 |
| T | 1.84 ± 0.23 | 1.44 ± 0.33 | 1.86 ± 0.40 | 1.46 ± 0.59 | 1.12 ± 0.83 | |
| OSI | S | 2.47 ± 0.87 | 2.15 ± 1.29 | 2.96 ± 1.8 | 3.57 ± 2.06 | 3.98 ± 1.23 |
| T | 2.1 ± 0.87 | 1.13 ± 0.84d | 1.78 ± 0.4 | 1.69 ± 0.83 | 3.03 ± 2.9d | |
| Total protein | S | 212.1 ± 14.4 | 209.7 ± 8.6 | 197.3 ± 8.6 | 210.9 ± 11.6 | 215.3 ± 4.34 |
| T | 175.9 ± 51.9 | 193.8 ± 30.7 | 195.1 ± 6.5 | 200.8 ± 12.8 | 212.2 ± 27.3 | |
aMean difference of GDH between stages 0 and III of tissue sample (P ≤ 0.05), bmean difference of LDH between stages IV and 0, I, II, and III of tissue sample (P ≤ 0.001, 0.001, 0.001, and ≤0.05, resp.), cmean difference between stages 0 and I, III, and IV (P ≤ 0.05) of blood sample, and dmean difference of OSI among stages I and IV in tissue of BCA (P ≤ 0.05) were statistically significant. NB: measuring units of GDH and LDH are in mU/l, GSH and GSSG were in μM/μg of total protein, TOS is in μmol H2O2 Eq/l, TAC is in mmol Trolox Eq/l, and total protein is in μg/ml.