Table 2.
Allele and genotypes frequencies of the ITGA4 −269A/C and +3061A/G polymorphism in AD patients and controls.
| SNP/model | Allele/genotype | AD subjects (n = 104) | Controls (n = 206) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | ||||
| −269 C/A | C | 170 (81.73%) | 339 (82.28%) | — | — | — | — |
| A | 38 (18.27%) | 73 (17.72%) | 0.87 | 1.04 (0.67–1.60) | — | — | |
|
| |||||||
| Codominant | CC | 66 (63.46%) | 133 (64.56%) | 1.00 | 1.00 | ||
| CA | 38 (36.54%) | 73 (35.44%) | 0.85 | 1.05 (0.64–1.71) | 1.00 | 1.00 (0.60–1.68) | |
| AA | 0 (00.00%) | 0 (00.00%) | — | — | — | — | |
|
| |||||||
| Dominant | CC | 66 (63.46%) | 133 (64.56%) | 1.00 | 1.00 | ||
| CA + AA | 38 (36.54%) | 73 (35.44%) | 0.85 | 1.05 (0.64–1.71) | 1.00 | 1.00 (0.60–1.68) | |
|
| |||||||
| Recessive | CC + CA | 104 (100.00%) | 206 (100.00%) | — | — | — | — |
| AA | 0 (00.00%) | 0 (00.00%) | — | — | — | — | |
|
| |||||||
| +3061 A/G | A | 135 (64.90%) | 294 (71.36%) | — | — | — | — |
| G | 73 (35.10%) | 118 (28.64%) | 0.10 | 1.35 (0.94–1.92) | — | — | |
|
| |||||||
| Codominant | AA | 39 (37.50%) | 106 (51.46%) | 1.00 | 1.00 | ||
| AG | 57 (54.81%) | 82 (39.80%) | 0.04 ∗ | 1.89 (1.15–3.11) | 0.11 | 1.76 (1.04–2.97) | |
| GG | 8 (7.70%) | 18 (8.74%) | — | 1.21 (0.49–3.00) | — | 1.35 (0.52–3.51) | |
|
| |||||||
| Dominant | AA | 39 (37.50%) | 106 (51.46%) | 1.00 | 1.00 | ||
| AG + GG | 65 (62.50%) | 100 (48.54%) | 0.02 ∗ | 1.77 (1.09–2.86) | 0.04 ∗ | 1.69 (1.02–2.81) | |
|
| |||||||
| Recessive | AA + AG | 96 (92.31%) | 188 (91.26%) | 1.00 | 1.00 | ||
| GG | 8 (7.69%) | 18 (8.74%) | 0.75 | 0.87 (0.37–2.07) | 0.99 | 1.01 (0.40–2.52) | |
|
| |||||||
| Overdominant | AA + GG | 47 (45.19% | 124 (60.20%) | 1.00 | 1.00 | ||
| AG | 57 (54.81%) | 82 (39.80%) | 0.01 ∗ | 1.83 (1.14–2.95) | 0.04 ∗ | 1.68 (1.02–2.77) | |
|
| |||||||
| Haplotypes | CA | 58.21% | 63.70% | 1.00 | 1.00 | ||
| CG | 23.52% | 18.58% | 0.16 | 1.41 (0.88–2.25) | 0.2 | 1.39 (0.84–2.29) | |
| AG | 11.57% | 10.06% | 0.44 | 1.29 (0.68–2.44) | 0.46 | 1.29 (0.66–2.53) | |
| AA | 6.70% | 7.66% | 0.95 | 0.97 (0.41–2.31) | 0.76 | 0.87 (0.35–2.18) | |
Allele and genotype frequencies are presented as absolute numbers with percentages in parentheses. OR: odds ratio; CI: confidence interval. Univariate analysis is based on χ2 test. Multivariate analysis is adjusted by gender, age, and APOE-ε4 positivity. ∗P ≤ 0.05 is considered as significant.