Table 4.
Allele and genotype frequencies of the ITGA4 −269A/C and +3061A/G polymorphism in APOE-ε4-negative AD patients and controls.
| SNP/model | Allele/genotype | AD subjects (n = 65) | Controls (n = 165) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | ||||
| −269 C/A | C | 106 (81.54%) | 271 (82.12%) | — | — | — | — |
| A | 24 (18.46%) | 59 (17.88%) | 0.88 | 1.04 (0.62–0.76) | — | — | |
|
| |||||||
| Codominant | CC | 41 (63.08%) | 106 (64.24%) | 1.00 | 1.00 | ||
| CA | 24 (36.92%) | 59 (35.76%) | 0.87 | 1.05 (0.58–1.91) | 1.00 | 1.00 (0.54–1.85) | |
| AA | 0 (00.00%) | 0 (00.00%) | — | — | — | — | |
|
| |||||||
| Dominant | CC | 41 (63.08%) | 106 (64.24%) | 1.00 | 1.00 | ||
| CA + AA | 24 (36.92%) | 59 (35.76%) | 0.87 | 1.05 (0.58–1.91) | 1.00 | 1.00 (0.54–1.85) | |
|
| |||||||
| Recessive | CC + CA | 65 (100.00%) | 165 (100.00%) | — | — | — | — |
| AA | 0 (00.00%) | 0 (00.00%) | — | — | — | — | |
|
| |||||||
| +3061 A/G | A | 82 (63.08%) | 237 (71.82%) | — | — | — | — |
| G | 48 (36.92%) | 93 (28.18%) | 0.07 | 1.49 (0.97–2.29) | — | — | |
|
| |||||||
| Codominant | AA | 22 (33.85%) | 88 (53.33%) | 1.00 | 1.00 | ||
| AG | 38 (58.46%) | 61 (36.97%) | 0.012 ∗ | 2.49 (1.34–4.62) | 0.025 ∗ | 2.37 (1.26–4.48) | |
| GG | 5 (7.69%) | 16 (9.70%) | — | 1.25 (0.41–3.78) | — | 1.34 (0.43–4.20) | |
|
| |||||||
| Dominant | AA | 22 (33.85%) | 88 (53.33%) | 1.00 | 1.00 | ||
| AG + GG | 43 (66.15%) | 77 (46.67%) | 0.007 ∗ | 2.23 (1.23–4.06) | 0.012 ∗ | 2.18 (1.18–4.03) | |
|
| |||||||
| Recessive | AA + AG | 60 (92.31%) | 149 (90.30%) | 1.00 | 1.00 | ||
| GG | 5 (7.69%) | 16 (9.70%) | 0.63 | 0.78 (0.27–2.21) | 0.77 | 0.85 (0.29–2.50) | |
|
| |||||||
| Overdominant | AA + GG | 27 (41.54%) | 104 (63.03%) | 1.00 | 1.00 | ||
| AG | 38 (58.46%) | 61 (36.97%) | 0.003 ∗ | 2.40 (1.34–4.31) | 0.008 ∗ | 2.26 (1.24–4.12) | |
|
| |||||||
| Haplotypes | CA | 56.88% | 63.97% | 1.00 | 1.00 | ||
| CG | 24.66% | 18.15% | 0.14 | 1.55 (0.87–2.75) | 0.17 | 1.51 (0.84–2.72) | |
| AG | 12.26% | 10.03% | 0.42 | 1.37 (0.63–2.96) | 0.40 | 1.40 (0.64–3.06) | |
| AA | 6.20% | 7.85% | 0.87 | 0.91 (0.30–2.77) | 0.67 | 0.78 (0.25–2.45) | |
Allele and genotype frequencies are presented as absolute numbers with percentages in parentheses. OR: odds ratio; CI: confidence interval. Univariate analysis is based on the χ2 test. Multivariate analysis is adjusted by gender and age. ∗P ≤ 0.05 is considered as significant.