Table 1.

Characteristics of selected clinical trials included in the meta-analysis.

Author name	Year	Sample size	Study design	Age	Age	Country	Comparators	Dosage/frequency/cycle		Outcomes	Follow-up period
				(treatment)	(control)			Suxiao jiuxin pills	Comparators
He	1995	48	RCT	42–60	40–57	China	Salvia	4# tid	3# tid	Hemorheology	4 weeks
Song	1995	149	RCT	55 ± 7.2	56 ± 6.9	China	Salvia	5# tid	3# tid	ECG, blood pressure, and heart rate	4 weeks
Wang	1996	60	RCT	NR	NR	China	Shexiang Baoxin pills	5# tid	3# tid	ECG and symptom	2 weeks
Ke	1996	72	RCT	45–79	46–78	China	Nitroglycerin	6# tid	0.5 mg Q8 h	ECG and symptom	4 weeks
Gao et al.	1996	147	RCT	36–85	35–84	China	Nitroglycerin	10#	0.5 mg	ECG and symptom	Immediately
Yun	1996	318	RCT	44–76	44–75	China	Isosorbide dinitrate	6–10# Q4–6 h	10# tid	ECG and symptom	2 weeks
Li	1998	154	RCT	58.93 ± 10.91	59.25 ± 10.12	China	Isosorbide dinitrate	0.2 g tid	10# tid	ECG and symptom	8 weeks
Feng and Zhou	2000	500	RCT	56 ± 4.24	55 ± 4.36	China	Salvia	10# tid	10# tid	ECG and symptom, Lipid profile and hemorheology	4 weeks
Mei	2000	128	RCT	NR	NR	China	Isosorbide dinitrate	6# tid	10# tid	ECG, symptom, and hemorheology	4 weeks
Xiao	2000	138	RCT	NR	NR	China	Isosorbide dinitrate	5# tid	10# tid	ECG and symptom	4 weeks
Ru	2000	90	RCT	45–70	NR	China	Salvia	5# tid	3# tid	ECG, symptom, lipid profile, and hemorheology	Unclear
Shu	2000	80	RCT	58.3 ± 7.24	57.2 ± 8.27	China	Isosorbide dinitrate	10# tid	10# tid	ECG and symptom	4 weeks
Yong	2000	148	RCT	45–72	47–70	China	Nitroglycerin	10#	5 mg	ECG, Symptom, blood pressure, and heart rate	Immediately
Guang	2000	248	RCT	NR	NR	China	Isosorbide dinitrate	5# tid	10# tid	Blood pressure, heart rate, and lipid profile	4 weeks
Li	2000	166	RCT	NR	NR	China	Nitroglycerin	5# tid	0.5 mg	ECG and symptom	2 weeks
Yu	2000	184	RCT	40–82	NR	China	Isosorbide dinitrate	5# tid	10# tid	ECG and symptom	15 days
Ya	2000	60	RCT	60–84	61–84	China	Nitroglycerin	5# tid	10# tid	ECG and symptom	4 weeks
Yuan	2000	102	RCT	61.68 ± 4.71	59.53 ± 5.62	China	Huoxin pills	5# tid	1# tid	ECG, symptom, and lipid profile	4 weeks
Duan and Yang	2002	80	RCT	42–79	41–75	China	Xinkeshu capsule	5# tid	4# tid	ECG, UCG, lipid profile, and hemorheology	4 weeks
Hai	2002	70	RCT	57 ± 7	59 ± 6	China	Isosorbide dinitrate	5# tid	10# tid	Symptom and hemorheology	4 weeks
Bu	2002	100	RCT	32–72	NR	China	Isosorbide dinitrate	4–6# tid	10–20# tid	ECG and symptom	Unclear
Pei	2003	102	RCT	56.1	55.2	China	Nitroglycerin	5# tid	Unclear	ECG, lipid profile, and hemorheology	8 weeks
Jin	2003	178	RCT	NR	NR	China	Isosorbide dinitrate	5# tid	20 mg qd	ECG, Symptom, lipid profile, and hemorheology	6 weeks
Ma	2004	116	RCT	63.4 ± 6.74	62.9 ± 7.84	China	Salvia	10# tid	3# tid	ECG, symptom, and hemorheology	4 weeks
Pei	2004	100	RCT	57.5 ± 10.2	63.1 ± 7.9	China	Xinkeshu capsule	6# tid	4# tid	ECG and symptom	4 weeks
Yue	2004	78	RCT	52–75	55–74	China	Placebo	5# tid	10# tid	ECG, UCG, and symptom	4 weeks
Hu	2004	80	RCT	51.56 ± 11.69	50.89 ± 11.02	China	Nitroglycerin	10# tid	0.5 mg tid	ECG and symptom	24 weeks
Zhu	2005	199	RCT	61.8	59.5	China	Glucose-insulin-potassium therapy	4–6# tid	Q2 d	ECG, symptom, and lipid profile	15 days
Wan	2005	64	RCT	NR	NR	China	Hesu pills	5# tid	1# tid	ECG and symptom	2 weeks
Shui	2006	73	RCT	43–78	45–76	China	Salvia	10# tid	10# tid	ECG and lipid profile	8 weeks
Cao and Zhang	2007	187	RCT	57.15 ± 5.38	58.77 ± 5.01	China	Salvia	6# tid	6# tid	ECG and symptom	2 weeks
Run	2007	90	RCT	NR	NR	China	Isosorbide dinitrate	10–15#	10 mg	ECG and symptom	Immediately
Wang	2008	60	RCT	63.9 ± 12.1	64.1 ± 11.2	China	Shexiang Baoxin pills	5# tid	1# tid	ECG and symptom	2 weeks
L. Wen	2009	88	RCT	56.7	56.8	China	Isosorbide dinitrate	5# tid	10# tid	ECG and symptom	8 weeks
Feng	2009	900	RCT	NR	NR	China	Salvia	6# tid	3# tid	ECG and symptom	4 weeks
S. L. Wen	2009	50	RCT	NR	NR	China	Tongxinluo pills	5# tid	4# tid	ECG and symptom	2 weeks
Guo	2012	60	RCT	42–70	43–73	China	Salvia	5# tid	3# tid	UCG and hemorheology	2 weeks
Qiao	2012	300	RCT	39–82	40–81	China	Salvia	5# tid	3# tid	ECG and symptom	4 weeks
Xin	2013	289	RCT	58.86 ± 10.57	57.69 ± 9.93	China	Standard therapy	10# tid	Blank	ECG and symptom	2 weeks
Long	2013	120	RCT	43–68	42–67	China	Standard therapy	10# tid	Blank	ECG and symptom	2 weeks
Li	2015	100	RCT	44–75	45–76	China	Salvia	6# tid	3# tid	ECG and symptom	4 weeks

NR: not reported; RCT: randomized controlled trial; tid: three times a day; Q4–6 h: every 4–6 h; Q8 h: every 8 h; ECG: electrocardiograph; UCG: ultrasound cardiogram; #: tablet.