Table 1.
Characteristics of the studies involved in our meta-analysis.
| Study | Experiment year | No. of OA patients | No. of controls | Measurement of uCTX-II | Quality assessment of literature (NOS) | Criteria for OA confirmation |
|---|---|---|---|---|---|---|
| E.B.Dam 2009 | 2009 | Total = 36 Female = 16 Male = 20 Knee OA = 36 |
Total = 122 Female = 60 Male = 62 |
ELISA (Nordic Bioscience, Denmark) | 6 grades | X-ray assessment |
| Eya Kalai 2012 | 2012 | Total = 125 Female = 125 Knee OA = 125 |
Total = 57 Female = 57 |
ELISA (Nordic Bioscience, Denmark) | 6 grades | American College of Rheumatology criteria for primary knee OA |
| MaryFran Sowers 2009 | 1997 | Total = 18 (KL = 2) = 14 (KL = 3,4) = 4 Female = 18 Knee OA = 18 |
Total = 54 | ELISA (Nordic Bioscience, Denmark) | 7 grades | X-ray image |
| MaryFran Sowers 2009 | 2009 | Total = 36 (KL = 2) = 16 (KL = 3,4) = 20 Female = 36 Knee OA = 36 |
Total = 36 | ELISA (Nordic Bioscience, Denmark) | 7 grades | c image |
| P Garnero 2001 | 2001 | Total = 67 Knee OA = 67 |
Total = 67 | ELISA (manufacturer not mentioned) | 6 grades | X-ray evidence (Joint Space Narrowing) |
| P Garnero 2006 | 2006 | Total = 40 Hip OA = 40 |
Total = 75 | ELISA (Nordic Bioscience, Denmark) | 3 grades | X-ray image |
| Nobuchika Tanishi 2009 | 2009 | Total = 190 Male = 78 Female = 112 (KL = 2) = 126 (KL = 3,4) = 64 Knee OA = 190 |
Total = 106 Male = 47 Female = 59 |
ELISA (Nordic Bioscience, Denmark) | 8 grades | X-ray image |
ELISA = enzyme-linked immunosorbent assay; KL = Kellgren–Lawrence; NOS = Newcastle–Ottawa Scale; OA = osteoarthritis; uCTX-II = urinary C-terminal telopeptide of type II collagen.