Model parameters were varied between the ranges, which are shown in parentheses. The length of the bar indicates the incremental cost-effectiveness ratio associated with the range. Reduced benefit indicates that all of the hazard ratios (HRs) for benefit are simultaneously attenuated toward the null from a zero percentage reduction (ie, hazard ratios are as reported in the Systolic Blood Pressure Intervention Trial) to 50% (ie, a 50% reduction in the benefit). AE indicates adverse event; CV, cardiovascular; ICER, incremental cost-effectiveness ratio; MI, myocardial infarction; QALY, quality-adjusted life-year; and QOL, quality of life.