Figure 5.

Restoration of TH levels and improvement of depressive behaviors of Ahi1 KO mice by Rev-Erbα inhibition. A–C, SR8278 (16 μg/mouse) or an equal volume of DMSO was microinfused into the VMB of control mice or Ahi1 KO mice. After 2 days, immunohistochemistry and TST were performed. A, fluorescence-TH staining of representative images in VTA were shown at AP −3.5 mm. B, intensity of TH immunofluorescence signals in A was analyzed. *, p < 0.05; ns, no statistical significance (n = 3). C, immobility time in TST was measured. Data are presented as means ± S.E. (error bars). **, p < 0.01; ns, no statistical significance (n = 6–8).