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Biosynthetic pathway for PGE2. Arachidonic acid is converted into prostaglandin H2 by COX-1 and COX-2 enzymes. Prostaglandin H2 is subsequently converted into PGE2 by mPGES-1, mPGES-2, and cytosolic prostaglandin E synthase (cPGES) enzymes. COX-2 and mPGES-1 are the enzymes that contribute to the bulk of PGE2 biosynthesis during inflammation.
